Treatment initiation information

Coverage Lookup & Access Resources

The following resources were created to help you and your patients get started with VYALEV

Educational videos

See how to program the pump, make dose adjustments, and administer VYALEV.

Watch videos

Infusion guidance

Review VYALEV administration steps and guidance on proper infusion site care.

Review guidance

Coverage lookup and access resources

FRM Guide
Billing & Coding Guide
Prior Authorization Form
Letter of Medical Necessity Form

Educational videos

Initial Dose Programming

See how to program the VYALEV Pump and set an initial dose for your patients.

Confirming & Adjusting Doses

See how to confirm doses prior to treatment initiation and make adjustments as needed.

The 5 Ps of VYALEV Administration

See how to administer VYALEV in 5 steps in this video.

Infusion site care

Select the infusion site: Select intact skin, free of irritation; avoid scarred tissue, broken skin, bony areas, highly mobile areas, or skin folds. Choose a site where you can pinch at least an inch of skin and fat. The 9-mm cannula is generally preferred, as it may help minimize dislodgement.1,2

The abdomen is the preferred site, staying at least 2 inches from the navel. The upper arm, thigh, and flank may be utilized.1,3*

*In a phase 1 study, healthy volunteers were administered VYALEV to different subcutaneous sites (ie, abdomen, arm, or thigh) using a 3-way crossover design. Pharmacokinetic analysis from this study showed that the 3 sites provided comparable CD and LD exposure, suggesting that VYALEV absorption is similar at the different subcutaneous sites.1

Infusion site preparation

Always clean the infusion site with water and antibacterial soap, followed by an alcohol swab prior to cannula placement, and ensure clean routine.2

WASH

Use soap and water to thoroughly scrub both hands—including under the nails—for 20 seconds. Wash the area with antibacterial, hypoallergenic soap on and around the infusion site, then dry with a clean paper towel.2,4,5

WIPE

Using clean hands, wipe the infusion site with an alcohol pad in an outward spiral motion (not back and forth) to avoid introducing bacteria into the site.4,6

WAIT

Allow the infusion site to air-dry for at least 60 seconds prior to cannula placement to ensure proper adhesion. Do not blow on or fan the area to accelerate drying.4,6

Cannula placement, rotation, and removal

Insert the cannula in different infusion site spots that follow a similar pattern.

Consider a pattern when rotating the infusion site.

Place the cannula: Use two fingers to pull the skin tight and insert the cannula at a 90-degree angle, secure the site properly, and change the site if pain, irritation, or pooling occurs. Directly insert at site that was cleaned. Cover the infusion site with transparent film dressing (ie, Tegaderm™) to secure the cannula and protect the site.2

Rotate and remove the cannula: When starting therapy, follow HCP direction on how often to change and rotate the cannula. Consider rotating daily until good skin tolerability is achieved. After that, rotate the cannula and infusion site at least every 3 days. Leave previous cannula in place for 1 hour. After removal, care for the skin by gentle massage (only on healthy skin) and consider applying a protective dressing. Select new infusion sites at least 1 inch from sites used within the previous 12 days.1,2,6

Develop a plan: Patients should regularly monitor infusion sites and seek prompt medical attention for persistent redness, inflammation, or signs of infection. Ensure each patient has a clear action plan for when to escalate care.1

The 5 Ps of VYALEV administration1,4

Review the 5 Ps (Plan, Prepare, Prime, Place, and Pump) and use them to help set your patients up for successful administration.

1.

PLAN
it out

Clean your hands and working surface. Then, gather all the supplies. 

2.

PREPARE
the syringe

Transfer all the medication from the vial to the syringe using the vial adapter. Attach the tip of the syringe to the tubing and place the full syringe inside the pump.

3.

PRIME
the tubing

Fill the infusion tubing with medication before connecting the cannula to the body.

4.

PLACE
the cannula

Place the cannula on clean skin using the insertion device. Connect the tubing to the cannula.

5.

PUMP
the medication

Start the pump to deliver the medication.

The infusion set may look different from the one shown here.

The medication vial, vial adapter, and syringe should be replaced at least once per day. The tubing, cannula, and insertion device should be replaced at least once every 3 days.

Get answers to frequently asked questions about VYALEV.

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